Dasabuvir : a new direct antiviral agent for the treatment of hepatitis C.

Abstract

INTRODUCTION:

Treatment of hepatitis C virus (HCV) infection with direct-acting antivirals (DAAs) has revolutionized the care of infected patients. Among these novel compounds are non-nucleoside analogs, which bind viral RNA-dependent RNA polymerase resulting in a conformational change inhibiting RNA synthesis.

AREAS COVERED:

Efficacy and tolerability of treatment regimens containing the non-nucleoside analog polymerase inhibitor dasabuvir (ABT-333).

EXPERT OPINION:

Dasabuvir-containing regimens achieve high rates of sustained virologic response in HCV genotype 1a and 1b-infected patients when combined with other DAAs, namely paritaprevir (ABT-450), ritonavir and ombitasvir (ABT-267). In the populations studied, dasabuvir seems to be well tolerated and safe. The major limitations of this novel drug are its genotype-restricted activity, the necessity to include ribavirin for HCV genotype 1a and the emergence of resistance if not combined with other DDAs.

• Authors: Juan Pablo Trivella, Julio Gutierrez, Paul Martin
• Journal: Expert opinion on pharmacotherapy (Expert Opin Pharmacother) Vol. 16 Issue 4 Pg. 617-24 (Mar 2015) ISSN: 1744-7666 [Electronic] England
• PMID: 25665437 (Publication Type: Journal Article)

Chemical References

• Anilides
• Antiviral Agents
• Carbamates
• Cyclopropanes
• Interferon-alpha
• Lactams, Macrocyclic
• Macrocyclic Compounds
• Sulfonamides
• ombitasvir
• Polyethylene Glycols
• Ribavirin
• Uracil
• Proline
• 2-Naphthylamine
• dasabuvir
• RNA-Dependent RNA Polymerase
• Valine
• paritaprevir

Topics

• 2-Naphthylamine
• Anilides (therapeutic use)
• Antiviral Agents (therapeutic use)
• Carbamates (therapeutic use)
• Clinical Trials as Topic
• Cyclopropanes
• Drug Resistance, Viral
• Drug Therapy, Combination
• Hepatitis C (drug therapy)
• Humans
• Interferon-alpha (chemistry, therapeutic use)
• Lactams, Macrocyclic
• Macrocyclic Compounds (therapeutic use)
• Polyethylene Glycols (chemistry, therapeutic use)
• Proline (analogs & derivatives)
• RNA-Dependent RNA Polymerase (metabolism)
• Ribavirin (therapeutic use)
• Sulfonamides (therapeutic use)
• Uracil (analogs & derivatives, therapeutic use)
• Valine