Clinical and microbiological effects of levofloxacin in the treatment of Aggregatibacter actinomycetemcomitans-associated periodontitis: a randomized placebo-controlled clinical trial.

Abstract

AIM:

To evaluate the clinical and microbiological effects of systemic levofloxacin (LFX) in subjects with Aggregatibacter actinomycetemcomitans-associated chronic periodontitis (AA-ACP).

MATERIALS AND METHODS:

Subjects with severe periodontitis with subgingival detection of A. actinomycetemcomitans were randomly divided into two treatment groups; a test group (n = 35) that received scaling and root planing (SRP) and LFX (500 mg o.d.) and a control group (n = 34) that received SRP and placebo (o.d.) for 10 days. Plaque index (PI), gingival index (GI), percent of sites with bleeding on probing (% BoP), probing depth (PD) and clinical attachment level (CAL) were recorded and subgingival plaque samples were cultivated for detection of A. actinomycetemcomitans at baseline to 6 months at various intervals.

RESULTS:

Subjects receiving LFX showed the greatest improvements in mean PD and CAL. The difference in the reduction of PD and CAL in the two groups was significant at 1, 3 and 6 months for PD and 3 and 6 months for CAL (p < 0.05). The inter-group difference in PI, GI and % BoP was not significant at any interval. Detectable levels of A. actinomycetemcomitans were significantly less in the test group 3 and 6 months post-therapy.

CONCLUSION:

Systemic LFX as an adjunct to SRP improves clinical outcomes and suppresses A. actinomycetemcomitans below detectable levels.

• Authors: A R Pradeep, Sonender Pal Singh, Santosh S Martande, Savitha B Naik, Nitish Kalra, N Priyanka
• Journal: Journal of the International Academy of Periodontology (J Int Acad Periodontol) Vol. 16 Issue 3 Pg. 67-77 (Jul 2014) ISSN: 1466-2094 [Print] England
• PMID: 25654959 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Placebos
• Levofloxacin

Topics

• Adult
• Aggregatibacter actinomycetemcomitans (drug effects, isolation & purification)
• Anti-Bacterial Agents (therapeutic use)
• Bacterial Load (drug effects)
• Chronic Periodontitis (drug therapy, microbiology)
• Combined Modality Therapy
• Dental Plaque (microbiology)
• Dental Plaque Index
• Dental Scaling (methods)
• Double-Blind Method
• Female
• Follow-Up Studies
• Gingival Hemorrhage (drug therapy, microbiology)
• Humans
• Levofloxacin (therapeutic use)
• Male
• Pasteurellaceae Infections (drug therapy)
• Periodontal Attachment Loss (drug therapy, microbiology)
• Periodontal Index
• Periodontal Pocket (drug therapy, microbiology)
• Placebos
• Root Planing (methods)
• Treatment Outcome