Chronic kidney disease and bone metabolism.

Abstract

Chronic kidney disease-related mineral and bone disease (CKD-MBD) is a syndrome defined as a systemic mineral metabolic disorder associated with CKD, and the term renal osteodystrophy indicates a pathomorphological concept of bone lesions associated with CKD-MBD. Cortical bone thinning, abnormalities in bone turnover and primary/secondary mineralization, elevated levels of circulating sclerostin, increased apoptosis in osteoblasts and osteocytes, disturbance of the coupling phenomenon, iatrogenic factors, accumulated micro-crackles, crystal/collagen disorientation, and chemical modification of collagen crosslinks are all possible candidates found in CKD that could promote osteopenia and/or bone fragility. Some of above factors are the consequences of abnormal systemic mineral metabolism but for others it seem unlikely. We have used the term uremic osteoporosis to describe the uremia-induced bone fragility which is not derived from abnormal systemic mineral metabolism. Interestingly, the disease aspect of uremic osteoporosis appears to be similar to that of senile osteoporosis.

• Authors: Junichiro James Kazama, Koji Matsuo, Yoshiko Iwasaki, Masafumi Fukagawa
• Journal: Journal of bone and mineral metabolism (J Bone Miner Metab) Vol. 33 Issue 3 Pg. 245-52 (May 2015) ISSN: 1435-5604 [Electronic] Japan
• PMID: 25653092 (Publication Type: Journal Article)

Topics

• Bone Density (physiology)
• Bone Diseases (metabolism)
• Humans
• Osteoblasts (metabolism)
• Osteocytes (metabolism)
• Osteoporosis (metabolism)
• Renal Insufficiency, Chronic (metabolism)