Simultaneous treatment with statins and aspirin reduces the risk of prostate cancer detection and tumorigenic properties in prostate cancer cell lines.

Abstract	Nowadays prostate cancer is the most common solid tumor in men from industrialized countries and the second leading cause of death. At the ages when PCa is usually diagnosed, mortality related to cardiovascular morbidity is high; therefore, men at risk for PCa frequently receive chronic lipid-lowering and antiplatelet treatment. The aim of this study was to analyze how chronic treatment with statins, aspirin, and their combination influenced the risk of PCa detection. The tumorigenic properties of these treatments were evaluated by proliferation, colony formation, invasion, and migration assays using different PCa cell lines, in order to assess how these treatments act at molecular level. The results showed that a combination of statins and aspirin enhances the effect of individual treatments and seems to reduce the risk of PCa detection (OR: 0.616 (95% CI: 0.467-0.812), P<0.001). However, if treatments are maintained, aspirin (OR: 1.835 (95% CI: 1.068-3.155), P=0.028) or the combination of both drugs (OR: 3.059 (95% CI: 1.894-4.939), P<0.001) represents an increased risk of HGPCa. As observed at clinical level, these beneficial effects in vitro are enhanced when both treatments are administered simultaneously, suggesting that chronic, concomitant treatment with statins and aspirin has a protective effect on PCa incidence.
Authors	M Olivan, M Rigau, E Colás, M Garcia, M Montes, T Sequeiros, L Regis, A Celma, J Planas, J Placer, J Reventós, I de Torres, A Doll, J Morote
Journal	BioMed research international (Biomed Res Int) Vol. 2015 Pg. 762178 ( 2015) ISSN: 2314-6141 [Electronic] United States
PMID	25649906 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Hydroxymethylglutaryl-CoA Reductase Inhibitors Aspirin
Topics	Aged Aspirin (pharmacology) Biopsy Case-Control Studies Cell Line, Tumor Cell Movement (drug effects) Cell Proliferation (drug effects) Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors (pharmacology) Male Prostate (pathology) Prostatic Neoplasms (epidemiology) Retrospective Studies

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