Abstract | OBJECTIVE: METHODS: The effects of SB on behavioural abnormalities (PPI deficits and hyperlocomotion) in mice after PCP administration were examined. Furthermore, effects of SB on tissue levels of amino acids were also examined. RESULTS: A single oral dose of SB (100, 300, or 1000 mg/kg) attenuated PPI deficits in mice after administration of PCP (3.0 mg/kg, s.c.) in a dose-dependent manner. In contrast, L-701,324 (10 mg/kg), an antagonist at the glycine site of the NMDA receptor, did not affect the effect of SB (1000 mg/kg) on PCP-induced PPI deficits. Furthermore, a single oral dose of SB (1000 mg/kg) significantly attenuated the hyperlocomotion in mice after administration of PCP (3.0 mg/kg, s.c.). However, a single oral dose of SB (1000 mg/kg) caused no changes to D- serine levels in plasma or in the frontal cortex, hippocampus, and striatum of these animals. CONCLUSION:
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Authors | Akiko Matsuura, Yuko Fujita, Masaomi Iyo, Kenji Hashimoto |
Journal | Acta neuropsychiatrica
(Acta Neuropsychiatr)
Vol. 27
Issue 3
Pg. 159-67
(Jun 2015)
ISSN: 1601-5215 [Electronic] England |
PMID | 25648314
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antipsychotic Agents
- Excitatory Amino Acid Antagonists
- Quinolones
- Receptors, N-Methyl-D-Aspartate
- Serine
- D-Amino-Acid Oxidase
- L 701324
- Phencyclidine
- Sodium Benzoate
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Topics |
- Animals
- Antipsychotic Agents
(pharmacology)
- Behavior, Animal
(drug effects)
- Chromatography, Liquid
(methods)
- Cognition Disorders
(drug therapy)
- D-Amino-Acid Oxidase
(antagonists & inhibitors)
- Drug Interactions
- Excitatory Amino Acid Antagonists
(pharmacology)
- Hyperkinesis
(drug therapy, metabolism)
- Male
- Mice
- Models, Animal
- Motor Activity
(drug effects)
- Phencyclidine
(pharmacology)
- Prepulse Inhibition
(drug effects)
- Quinolones
(pharmacology)
- Receptors, N-Methyl-D-Aspartate
(antagonists & inhibitors)
- Serine
(blood, metabolism)
- Sodium Benzoate
(pharmacology)
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