Serum neurokinin B levels in newly diagnosed nondipper hypertensive patients.

Abstract

OBJECTIVE:

Cardiovascular diseases are more common in patients with nondipper hypertension (NDHT) compared with those with dipper hypertension (DHT). The aim of this study is to evaluate the serum neurokinin B levels in DHT and NDHT patients.

METHODS:

The study population included newly diagnosed hypertensive patients who were not under antihypertensive treatment. A total of 77 patients were evaluated with ambulatory blood pressure monitoring and divided into two groups: NDHT (n=42) and DHT (n=35). Plasma neurokinin B levels were measured using the ELISA method.

RESULTS:

Serum neurokinin B levels were significantly higher in the NDHT group compared with the DHT group [254 (180-888) and 207 (116-752) pg/ml, respectively; P=0.024]. There is a positive correlation between the mean night-time systolic blood pressure and plasma neurokinin levels (r=0.590; P<0.001). On regression analysis, neurokinin B level was only found to be related to the mean night-time systolic blood pressure (unstandardized β=-22.02±9.59; P<0.001).

CONCLUSION:

Plasma neurokinin B level is higher in patients with NDHT, indicating an unfavorable cardiovascular prognosis. There is a need for further studies that search for the relation between serum neurokinin B levels and NDHT.

• Authors: Dursun C Akkoyun, Aydin Akyuz, Seref Alpsoy, Murat Aydin, Kubilay Erselcan
• Journal: Blood pressure monitoring (Blood Press Monit) Vol. 20 Issue 3 Pg. 144-9 (Jun 2015) ISSN: 1473-5725 [Electronic] England
• PMID: 25647283 (Publication Type: Journal Article, Multicenter Study, Observational Study, Randomized Controlled Trial)

Chemical References

• Neurokinin B

Topics

• Adult
• Aged
• Humans
• Hypertension (blood, diagnosis)
• Middle Aged
• Neurokinin B (blood)
• Prognosis
• Prospective Studies