Is there any potential clinical impact of serum phosphorus and magnesium in patients with lung cancer at first diagnosis? A multi-institutional study.
Abstract | BACKGROUND: MATERIALS AND METHODS: Retrospectively, 130 patients were selected at the time of diagnosis oflung cancer (100 with NSCLC and 30 with SCLC), before the initialization of any chemo- radiotherapy. The median age was 67 (range 29-92). IA, IB, IIA, IIB, IIIA, IIIB and IV stages were present in 3, 4, 19, 6, 25, 8, and 65 patients, respectively. After centrifugation, the levels of serum P and Mg were measured using the nephelometric method/ photometry and evaluated before any type of treatment. RESULTS: Higher than normal levels of P were found in 127/130 patients, while only four patients had elevated Mg serum values. In terms of Spearman test, higher P serum values correlated with either stage (rho=- 0.334, p<0.001) or OS (rho=-0.212, p=0.016). Additionally, a significant negative correlation of Mg serum levels was found with stage of disease (rho=-0.135, P=0.042). On multivariate cox-regression survival analysis, only stage (p<0.01), performance status (p<0.01) and P serum (p=0.045) showed a significant prognostic value. CONCLUSIONS: Our study indicated that pre-treatment P serum levels in lung cancer patients are higher than the normal range. Moreover, P and Mg serum levels are predictive of stage of disease. Along with stage and performance status, the P serum levels had also a significant impact on survival. This information may be important for stratifying patients to specific treatment protocols or intensifying their therapies. However, larger series are now needed to confirm our results.
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Authors | Vassilis Kouloulias, Maria Tolia, Nikolaos Tsoukalas, Christos Papaloucas, Kyriaki Pistevou-Gombaki, Anna Zygogianni, Kyriaki Mystakidou, John Kouvaris, Marios Papaloucas, Amanda Psyrri, George Kyrgias, Vasiliki Gennimata, Konstantinos Leventakos, Ioannis Panayiotides, Zoi Liakouli, Nikolaos Kelekis, Aristofanis Papaloucas |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 16
Issue 1
Pg. 77-81
( 2015)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 25640394
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
- Biomarkers, Tumor
- Phosphorus
- Magnesium
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(blood)
- Carcinoma, Non-Small-Cell Lung
(blood, diagnosis, mortality)
- Female
- Humans
- Lung Neoplasms
(blood, diagnosis, mortality)
- Magnesium
(blood)
- Male
- Middle Aged
- Neoplasm Staging
- Phosphorus
(blood)
- Prognosis
- Retrospective Studies
- Small Cell Lung Carcinoma
(blood, diagnosis, mortality)
- Survival Analysis
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