Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study.

Abstract

INTRODUCTION:

Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer.

METHODS:

A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary questionnaire from 1992 to 2000, and were followed-up until 2010 for incidence of breast cancer. Hazard ratios (HR) of breast cancer by country-specific, as well as cohort-wide categories of beverage intake were estimated.

RESULTS:

During an average follow-up of 11 years, 1064 premenopausal, and 9134 postmenopausal breast cancers were diagnosed. Caffeinated coffee intake was associated with lower risk of postmenopausal breast cancer: adjusted HR=0.90, 95% confidence interval (CI): 0.82 to 0.98, for high versus low consumption; Ptrend=0.029. While there was no significant effect modification by hormone receptor status (P=0.711), linear trend for lower risk of breast cancer with increasing caffeinated coffee intake was clearest for estrogen and progesterone receptor negative (ER-PR-), postmenopausal breast cancer (P=0.008). For every 100 ml increase in caffeinated coffee intake, the risk of ER-PR- breast cancer was lower by 4% (adjusted HR: 0.96, 95% CI: 0.93 to 1.00). Non-consumers of decaffeinated coffee had lower risk of postmenopausal breast cancer (adjusted HR=0.89; 95% CI: 0.80 to 0.99) compared to low consumers, without evidence of dose-response relationship (Ptrend=0.128). Exclusive decaffeinated coffee consumption was not related to postmenopausal breast cancer risk, compared to any decaffeinated-low caffeinated intake (adjusted HR=0.97; 95% CI: 0.82 to 1.14), or to no intake of any coffee (HR: 0.96; 95%: 0.82 to 1.14). Caffeinated and decaffeinated coffee were not associated with premenopausal breast cancer. Tea intake was neither associated with pre- nor post-menopausal breast cancer.

CONCLUSIONS:

Higher caffeinated coffee intake may be associated with lower risk of postmenopausal breast cancer. Decaffeinated coffee intake does not seem to be associated with breast cancer.

• Authors: Nirmala Bhoo-Pathy, Petra H M Peeters, Cuno S P M Uiterwaal, H Bas Bueno-de-Mesquita, Awang M Bulgiba, Bodil Hammer Bech, Kim Overvad, Anne Tjønneland, Anja Olsen, Françoise Clavel-Chapelon, Guy Fagherazzi, Florence Perquier, Birgit Teucher, Rudolf Kaaks, Madlen Schütze, Heiner Boeing, Pagona Lagiou, Philippos Orfanos, Antonia Trichopoulou, Claudia Agnoli, Amalia Mattiello, Domenico Palli, Rosario Tumino, Carlotta Sacerdote, Franzel J B van Duijnhoven, Tonje Braaten, Eiliv Lund, Guri Skeie, María-Luisa Redondo, Genevieve Buckland, Maria José Sánchez Pérez, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Elisabet Wirfält, Peter Wallström, Ingegerd Johansson, Lena Maria Nilsson, Kay-Tee Khaw, Nick Wareham, Naomi E Allen, Timothy J Key, Sabina Rinaldi, Isabelle Romieu, Valentina Gallo, Elio Riboli, Carla H van Gils
• Journal: Breast cancer research : BCR (Breast Cancer Res) Vol. 17 Pg. 15 (Jan 31 2015) ISSN: 1465-542X [Electronic] England
• PMID: 25637171 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Coffee
• Tea

Topics

• Adult
• Aged
• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (epidemiology, etiology, metabolism)
• Coffee
• Cohort Studies
• Europe (epidemiology)
• Female
• Follow-Up Studies
• Humans
• Menopause
• Middle Aged
• Registries
• Risk Assessment
• Risk Factors
• Surveys and Questionnaires
• Tea