Abstract | BACKGROUND: A new serogroup A meningococcal conjugate vaccine (PsA-TT, MenAfriVac™) has been developed to combat devastating serogroup A Neisseria meningitis (MenA) epidemics in Africa. A mass immunization campaign targeting 1-29 year olds was conducted in Burkina Faso in December 2010. Protection of subsequent infant cohorts will be necessary through either introduction of PsA-TT into the routine Expanded Programme on Immunization (EPI) or periodic repeat mass vaccination campaigns. OBJECTIVES: To inform future immunization policy for PsA-TT vaccination of infants through a comparison of PsA-TT campaign vaccination coverage and routine measles-containing vaccine (MCV) coverage in Burkina Faso. METHODS: A national survey was conducted in Burkina Faso during December 17-27, 2011 using stratified cluster sampling to assess PsA-TT vaccine coverage achieved by the 2010 nationwide immunization campaign among 2-30 year olds and routine MCV coverage among 12-23 month olds. Coverage estimates and 95% Confidence Intervals (CI) were calculated, reasons for non-vaccination and methods of campaign communication were described, and a multivariable analysis for factors associated with vaccination was conducted. RESULTS: National overall PsA-TT campaign coverage was 95.9% (95% CI: 95.0-96.7) with coverage greater than 90% all 13 regions of Burkina Faso. National overall routine MCV coverage was 92.5% (95% CI: 90.5-94.1), but ranged from 75.3% to 95.3% by region. The primary predictor for PsA-TT vaccination among all age groups was a head of household informed of the campaign. PsA-TT vaccination was more likely in residents of rural settings, whereas MCV vaccination was more likely in residents of urban settings. CONCLUSION: Overall national vaccination rates in Burkina Faso were similar for PsA-TT and MCV vaccine. The regions with MCV coverage below targets may be at risk for sub-optimal vaccination coverage if PsA-TT is introduced in EPI. These results highlight the need for assessments of routine vaccination coverage to guide PsA-TT immunization policy in meningitis belt countries.
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Authors | Sarah A Meyer, Jean Ludovic Kambou, Amanda Cohn, James L Goodson, Brendan Flannery, Isaïe Medah, Nancy Messonnier, Ryan Novak, Fabien Diomande, Mamoudou H Djingarey, Thomas A Clark, Issaka Yameogo, Amadou Fall, Kathleen Wannemuehler |
Journal | Vaccine
(Vaccine)
Vol. 33
Issue 12
Pg. 1492-8
(Mar 17 2015)
ISSN: 1873-2518 [Electronic] Netherlands |
PMID | 25636915
(Publication Type: Journal Article)
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Copyright | Published by Elsevier Ltd. |
Chemical References |
- Measles Vaccine
- MenAfriVac
- Meningococcal Vaccines
- Vaccines, Conjugate
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Topics |
- Adolescent
- Adult
- Africa
- Burkina Faso
(epidemiology)
- Child
- Child, Preschool
- Health Care Surveys
(statistics & numerical data)
- Health Policy
- Humans
- Immunization Programs
(legislation & jurisprudence, statistics & numerical data)
- Infant
- Male
- Measles Vaccine
(administration & dosage)
- Meningitis, Meningococcal
(prevention & control)
- Meningococcal Vaccines
(administration & dosage)
- Neisseria meningitidis, Serogroup A
(immunology)
- Public Health Surveillance
- Rural Health Services
- Vaccines, Conjugate
(administration & dosage)
- Young Adult
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