Abstract | AIM: METHODS: Semi-quantitative reverse transcriptase polymerase chain reaction, in situ hybridization and immunohistochemical streptavidin- biotin- peroxidase methods were used to detect expression of RhoC mRNA and protein, and VEGF protein in 62 cases with esophageal squamous cell carcinoma, 31 cases with adjacent atypical hyperplastic tissues, and 62 cases with normal esophageal mucosa. CD105 antibody labeling was used to measure microvascular density. Expression levels were compared according to clinicopathologic and patient parameters. RESULTS: CONCLUSION:
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Authors | Zhi-Hua Zhao, Yan Tian, Jian-Pin Yang, Jun Zhou, Kui-Sheng Chen |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 21
Issue 3
Pg. 905-12
(Jan 21 2015)
ISSN: 2219-2840 [Electronic] United States |
PMID | 25624724
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, CD
- ENG protein, human
- Endoglin
- RNA, Messenger
- Receptors, Cell Surface
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- RHOC protein, human
- rho GTP-Binding Proteins
- rhoC GTP-Binding Protein
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Topics |
- Adult
- Aged
- Antigens, CD
(analysis)
- Carcinoma, Squamous Cell
(blood supply, enzymology, genetics, pathology)
- Case-Control Studies
- Endoglin
- Esophageal Neoplasms
(blood supply, enzymology, genetics, pathology)
- Esophageal Squamous Cell Carcinoma
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- In Situ Hybridization
- Lymphatic Metastasis
- Male
- Microvessels
(chemistry, pathology)
- Middle Aged
- Neoplasm Grading
- Neoplasm Invasiveness
- Neovascularization, Pathologic
- RNA, Messenger
(analysis)
- Receptors, Cell Surface
(analysis)
- Reverse Transcriptase Polymerase Chain Reaction
- Up-Regulation
- Vascular Endothelial Growth Factor A
(analysis, genetics)
- rho GTP-Binding Proteins
(analysis, genetics)
- rhoC GTP-Binding Protein
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