Osteoporosis (OP) is a disease which causes bone loss and fractures, leading to severe
pain and
deformity. This study has aimed to assess the effects of pulsed wave
low-level laser therapy (PW
LLLT) on cortical bone in two experimental models of OP in rats. There were four ovariectomized (OVX-d) groups and four
dexamethasone-treated groups. The healthy group were considered for baseline evaluations. At 14 weeks following
ovariectomy, the OVX-d rats were further subdivided into the following: control rats with OP, OVX-d rats that received
alendronate (1 mg/kg), OVX-d rats treated with
LLLT, and OVX-d rats treated with
alendronate and
LLLT. The remaining rats received
dexamethasone for 5 weeks and were divided into four groups: control,
alendronate-treated rats (1 mg/kg),
laser-treated rats, and
laser-treated rats with concomitant administration of
alendronate. The rats received
alendronate for 30 days.
LLLT (890 nm, 80 Hz, 0.972 J/cm(2)) was performed on the tibias three times per week for 8 weeks. After 8 weeks, tibias were extracted and submitted to a three-point bending test. PW
LLLT did not increase the biomechanical parameters of osteoporotic bones compared to controls and healthy rats. PW
LLLT associated with
alendronate treatment significantly increased stress high load in OVX-d rats compared to the healthy group. PW
LLLT at the current study parameters failed to cause beneficial biomechanical effects in the examined osteoporotic cortical bones. PW
LLLT associated with
alendronate treatment produced a more remarkable effect on bone strength in the ovariectomized induced OP rat model.