Alkylresorcinols (ARs) are
phytochemicals mainly associated with rye/
wheat bran. Plasma ARs and their plasma and urine metabolites are considered as
biomarkers for whole-grain rye/wheat intake. However ARs metabolite day and night variations have not been studied in
prostate cancer patients yet. We investigated ARs metabolites 3, 5-dihydroxy-benzoic
acid (DHBA), and 3-(3, 5-dihydroxyphenyl)-1-propanoic
acid (
DHPPA) in urine and plasma in
prostate cancer patients and in control group.
DHPPA in 12-h overnight urine correlated with the intake of rye bread and bread fiber across short time periods (3 days). Plasma
DHPPA concentration was significantly greater in the
prostate cancer group than in the control group.
DHPPA and DHBA excretion was significantly higher in the overnight urine than in day urine in the
prostate cancer group but not in the control group.
DHPPA concentration in plasma in the
prostate cancer group did not depend on the intake of rye bread in the previous day, suggesting an impaired metabolism of ARs metabolites in the
prostate cancer group. The results of this study suggest
DHPPA in 12-h overnight urine as a
biomarker to estimate the intake of rye bread and bread fiber.