Incomplete vitreomacular traction release using intravitreal ocriplasmin.

Abstract

PURPOSE:

To report the clinical course of our first 7 consecutive patients treated with intravitreal ocriplasmin (Jetrea(®)).

METHODS:

Retrospective case series of the first 7 patients treated with ocriplasmin between January and December 2013 at an academic tertiary care center.

RESULTS:

The average age was 78.4 years (range: 63-92). Five patients were pseudophakic and 2 patients were phakic in the injected eye. The median baseline visual acuity (VA) was 20/60 (range: 20/25 to 20/200). The median 1-month postinjection VA was 20/70, with a mean loss of 2 lines of VA among all patients. None of the patients had complete resolution of their vitreomacular traction or macular hole at 1 month of follow-up. Three patients had subsequent pars plana vitrectomy and membrane peeling surgery. The mean follow-up period for those who did not undergo vitrectomy was 9 months (range: 1-13). One patient with known ocular hypertension had an increase in intraocular pressure requiring topical pressure-lowering eyedrops. There were no cases of postinjection uveitis, endophthalmitis, retinal tears, or retinal detachment.

CONCLUSIONS:

While ocriplasmin may be a viable pharmacological agent for vitreolysis, we present a series of patients that all had incomplete resolution of vitreomacular traction with and without full-thickness macular hole. There was an associated reduction in VA after ocriplasmin treatment at 1 month of follow-up. Careful analysis of the vitreoretinal interface and comorbid eye conditions is required to optimize outcome success with ocriplasmin.

• Authors: Eric K Chin, David R P Almeida, Elliott H Sohn, H Culver Boldt, Vinit B Mahajan, Karen M Gehrs, Stephen R Russell, James C Folk
• Journal: Case reports in ophthalmology (Case Rep Ophthalmol) 2014 Sep-Dec Vol. 5 Issue 3 Pg. 455-62 ISSN: 1663-2699 [Print] Switzerland
• PMID: 25606039 (Publication Type: Case Reports)