[Complete response of locally recurrent anorectal cancer to proton beam therapy alone--a case report].

Abstract

We report a case of locally recurrent anorectal cancer treated with proton beam therapy (PBT) alone that led to a clinically complete response. A 70-year-old woman with paraparesis due to infantile paralysis underwent abdominoperineal resection (APR) and D3 lymphadenectomy for anorectal cancer (PERb, type 2, 50×40 mm, muc-tub1, M1a[lung], Stage IV a]. Three months after APR, right middle and right lower lobectomies were performed for synchronous lung metastases. Adjuvant chemotherapy was not administered. One year and 8 months after APR, computed tomography (CT) showed local recurrence of the tumor (29×28 mm), which contacted the right ischial spine. Pelvic exenteration combined with sacral resection was not performed because of the patient's poor performance status. PBT (70 Gy [RBE]/25 F/5 week) was administered for treatment of the recurred tumor. CT revealed that the tumor disappeared 1 year after PBT, which was defined as complete response. The patient is alive and has not experienced recurrence for 7 years.

• Authors: Masafumi Ie, Tomohiro Yamaguchi, Yusuke Kinugasa, Sumito Sato, Yushi Yamakawa, Hiroyasu Kagawa, Hiroyuki Tomioka, Akio Shiomi, Hiroshi Fuji, Shigeyuki Murayama
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 41 Issue 13 Pg. 2623-5 (Dec 2014) ISSN: 0385-0684 [Print] Japan
• PMID: 25596061 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Aged
• Female
• Humans
• Lung Neoplasms (radiotherapy, secondary)
• Multimodal Imaging
• Positron-Emission Tomography
• Proton Therapy
• Rectal Neoplasms (pathology, radiotherapy, surgery)
• Recurrence
• Tomography, X-Ray Computed