Pamidronate attenuates diastolic dysfunction induced by myocardial infarction associated with changes in geometric patterning.

Abstract

BACKGROUND/AIMS:

The aim of this study was to evaluate the influence of pamidronate on ventricular remodeling after myocardial infarction.

METHODS:

Male Wistar rats were assigned to four groups: a sham group, in which animals were submitted to simulated surgery and received weekly subcutaneous injection of saline (S group; n=14); a group in which animals received weekly subcutaneous injection of pamidronate (3 mg/kg of body weight) and were submitted to simulated surgery (SP group, n=14); a myocardial infarction group, in which animals were submitted to coronary artery ligation and received weekly subcutaneous injection of saline (MI group, n=13); and a myocardial infarction group with pamidronate treatment (MIP group, n=14). The rats were observed for three months.

RESULTS:

Animals submitted to MI had left chamber enlargement and worse diastolic and systolic function compared with SHAM groups. E/A ratio, LV posterior and relative wall thickness were lower in the MIP compared with the MI group. There was no interaction between pamidronate administration and MI on systolic function, myocyte hypertrophy, collagen content, and calcium handling proteins.

CONCLUSION:

Pamidronate attenuates diastolic dysfunction following MI.

• Authors: Andréa F Gonçalves, Luiz Henrique Congio, Priscila P dos Santos, Bruna P M Rafacho, Bruna L B Pereira, Renan F T Claro, Nara A Costa, Fernanda Chiuso-Minicucci, Paula S Azevedo, Bertha F Polegato, Katashi Okoshi, Elenize J Pereira, Marina P Okoshi, Sergio A R Paiva, Leonardo A M Zornoff, Marcos F Minicucci
• Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (Cell Physiol Biochem) Vol. 35 Issue 1 Pg. 259-69 ( 2015) ISSN: 1421-9778 [Electronic] Germany
• PMID: 25591768 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 S. Karger AG, Basel.

Chemical References

• Atp2a2 protein, rat
• Cell Adhesion Molecules
• Diphosphonates
• Postn protein, rat
• Tissue Inhibitor of Metalloproteinase-1
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9
• Sarcoplasmic Reticulum Calcium-Transporting ATPases
• Pamidronate

Topics

• Animals
• Cell Adhesion Molecules (metabolism)
• Diphosphonates (pharmacology, therapeutic use)
• Echocardiography
• Male
• Matrix Metalloproteinase 2 (metabolism)
• Matrix Metalloproteinase 9 (metabolism)
• Myocardial Infarction (drug therapy, metabolism, physiopathology)
• Myocardium (metabolism, pathology)
• Pamidronate
• Rats
• Rats, Wistar
• Sarcoplasmic Reticulum Calcium-Transporting ATPases (metabolism)
• Tissue Inhibitor of Metalloproteinase-1 (metabolism)
• Ventricular Remodeling (drug effects)