Does atopy influence the effectiveness of treatment of adenoid hypertrophy with mometasone furoate?

Abstract

BACKGROUND:

The effect of topical mometasone for adenoid hypertrophy treatment is well established. Nevertheless, the influence of atopy on this treatment remains ill defined.

OBJECTIVE:

This study aims to compare the effects of topical mometasone furoate treatment on the adenoid tissue between atopic and nonatopic children.

METHODS:

Fifty-one children with obstructive respiratory complaints underwent a semistructured clinical questionnaire on nasal symptoms, prick test, and nasoendoscopy. Nasoendoscopic images were digitalized, and both adenoid and nasopharyngeal areas were measured in pixels; the relative adenoid/nasopharyngeal area was calculated. Patients were initially treated for 40 days with nasal saline solution. In a subsequent 40-day period, topical mometasone furoate (total dose, 100 μg/day) was used.

RESULTS:

Topical mometasone significantly improved nasal obstruction, snoring, and apnea and also significantly reduced the adenoid tissue area related to the nasopharynx (p < 0.0001). Treatment with this glucocorticoid was not influenced by atopy, neither for symptoms nor for adenoid area.

CONCLUSION:

Topical mometasone furoate significantly reduced the adenoid tissue area and led to a supplementary improvement of nasal symptoms. This improvement was similar for atopic and nonatopic patients.

• Authors: Renato M Rezende, Flávia S Amato, Aline P Barbosa, Ulissis P Menezes, Patrícia Rezende, Virgínia P L Ferriani, Wilma T Anselmo-Lima, Fabiana C P Valera
• Journal: American journal of rhinology & allergy (Am J Rhinol Allergy) 2015 Jan-Feb Vol. 29 Issue 1 Pg. 54-6 ISSN: 1945-8932 [Electronic] United States
• PMID: 25590321 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Pregnadienediols
• Mometasone Furoate

Topics

• Adenoids (pathology)
• Administration, Topical
• Anti-Inflammatory Agents (therapeutic use)
• Child
• Female
• Humans
• Hypertrophy
• Male
• Mometasone Furoate
• Pregnadienediols (administration & dosage, therapeutic use)