Effects of Axial Length and Age on Circumpapillary Retinal Nerve Fiber Layer and Inner Macular Parameters Measured by 3 Types of SD-OCT Instruments.

Abstract

PURPOSES:

To evaluate the effects of axial length and age on the circumpapillary retinal nerve fiber layer (cpRNFL) and the inner macular parameters measured using 3 spectral-domain optical coherence tomography (OCT) instruments.

METHODS:

A total of 102 normal eyes (1 eye per subject) were imaged using Cirrus, RTVue, and 3D-OCT. The cpRNFL and the macular retinal nerve fiber layer (mRNFL), the ganglion cell layer+inner plexiform layer (GCLIPL), and the mRNFL+GCLIPL ganglion cell complex, GCC thicknesses were analyzed. The correlations between these values and the axial length or age were evaluated using a partial correlation analysis. These correlations were corrected using the axial length-related magnification effect.

RESULTS:

All but the nasal quadrant cpRNFL thicknesses and GCC thicknesses obtained using the 3 OCT instruments were significantly correlated with age. The average cpRNFL thickness and GCC thickness measured using the Cirrus and RTVue, but not by the 3D-OCT, had a negative correlation with the axial length. The temporal quadrant cpRNFL thickness measured using the 3 instruments was positively correlated with the axial length. The magnification correction made the most correlations positive.

CONCLUSIONS:

The average cpRNFL and GCC thicknesses measured using these 3 instruments decreased with age. The axial length affected the cpRNFL and GCC thicknesses as measured using the Cirrus and RTVue; this effect likely depended on the fundus area of analyses.

• Authors: Kaori Ueda, Akiyasu Kanamori, Azusa Akashi, Mari Tomioka, Yuki Kawaka, Makoto Nakamura
• Journal: Journal of glaucoma (J Glaucoma) Vol. 25 Issue 4 Pg. 383-9 (Apr 2016) ISSN: 1536-481X [Electronic] United States
• PMID: 25580890 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Aging (physiology)
• Axial Length, Eye (anatomy & histology)
• Cross-Sectional Studies
• Female
• Humans
• Intraocular Pressure
• Male
• Middle Aged
• Nerve Fibers
• Retina (anatomy & histology)
• Retinal Ganglion Cells (cytology)
• Tomography, Optical Coherence (instrumentation)