Abstract | BACKGROUND:
Pycnogenol is extracted from the pine bark of a tree known as Pinus pinaster that has variety biological effects. However, its anticancer activity has not yet been completely studied. The aim of this study is to investigate anticancer effect of pycnogenol in MC-3 human mucoepidermoid carcinoma (MEC) cell line. METHODS: We describe the effect of anti- cancer of pycnogenol in MC-3 human oral MEC cells using trypan blue exclusion assay, 3-(4,5-dimethylthiazol-2-yl)-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tetrazolium (MTS) assay, Western blot, preparation of cytosolic and nuclear fractions, immunocytochemistry and reverse transcriptase polymerase chain reaction. RESULTS: CONCLUSIONS: Overall, pycnogenol may be a fascinating therapeutic drug candidate for the treatment of MEC.
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Authors | In-Hyoung Yang, Ji-Ae Shin, Sung-Dae Cho |
Journal | Journal of cancer prevention
(J Cancer Prev)
Vol. 19
Issue 4
Pg. 265-72
(Dec 2014)
ISSN: 2288-3649 [Print] Korea (South) |
PMID | 25574461
(Publication Type: Journal Article)
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