Abstract |
The results of a patient with exudative age-related macular degeneration who received an intravitreal injection of ziv-aflibercept ( Zaltrap; Sanofi-Aventis, Paris, France) in the right eye are described. A complete ocular examination as well as color fundus photography, optical coherence tomography, fluorescein angiography, microperimetry, full-field electroretinography, and multifocal electroretinography were performed and repeated 1 month later. The patient experienced subjective and objective improvement of visual acuity with a decrease in intraretinal and subretinal fluid. Microperimetric improvement also occurred. Electroretinographic changes were noted from baseline to the 30-day follow-up. No adverse events were observed at any time point. Ziv-aflibercept demonstrated short-term safety and efficacy after intravitreal administration for neovascular macular degeneration.
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Authors | João Rafael de Oliveira Dias, Camilla Oliveira Xavier, André Maia, Nilva Simeren Bueno de Moraes, Carsten Meyer, Michel Eid Farah, Eduardo Büchele Rodrigues |
Journal | Ophthalmic surgery, lasers & imaging retina
(Ophthalmic Surg Lasers Imaging Retina)
Vol. 46
Issue 1
Pg. 91-4
(Jan 2015)
ISSN: 2325-8179 [Electronic] United States |
PMID | 25559518
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright 2015, SLACK Incorporated. |
Chemical References |
- Angiogenesis Inhibitors
- Recombinant Fusion Proteins
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- aflibercept
- Receptors, Vascular Endothelial Growth Factor
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Topics |
- Aged, 80 and over
- Angiogenesis Inhibitors
(therapeutic use)
- Electroretinography
- Fluorescein Angiography
- Humans
- Intravitreal Injections
- Male
- Photography
- Receptors, Vascular Endothelial Growth Factor
(therapeutic use)
- Recombinant Fusion Proteins
(therapeutic use)
- Tomography, Optical Coherence
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
- Visual Acuity
(physiology)
- Wet Macular Degeneration
(diagnosis, drug therapy, physiopathology)
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