Abstract | AIMS: METHODS AND RESULTS: We describe the clinicopathological and immunophenotypic findings of four EBV-positive plasmacytomas arising in immunocompetent patients. These tumours were characterized by diffuse proliferation of mature-appearing plasma cells intermixed with a briskly reactive, CD8-positive, TIA-1-positive cytotoxic T-cell infiltrate. Long-term follow-up was available for all patients, and all were alive and free of disease at last follow-up (median 43.4 months). CONCLUSIONS: We suggest the term EBV-positive plasmacytoma in immunocompetent patients for these lesions. It is essential to distinguish these tumours from plasmablastic lymphoma, as the latter diagnosis is associated with a much poorer prognosis, and patients require much more aggressive therapy.
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Authors | Sanam Loghavi, Joseph D Khoury, L Jeffrey Medeiros |
Journal | Histopathology
(Histopathology)
Vol. 67
Issue 2
Pg. 225-34
(Aug 2015)
ISSN: 1365-2559 [Electronic] England |
PMID | 25556356
(Publication Type: Journal Article)
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Copyright | © 2015 John Wiley & Sons Ltd. |
Chemical References |
- CD8 Antigens
- Poly(A)-Binding Proteins
- RNA, Viral
- T-Cell Intracellular Antigen-1
- TIA1 protein, human
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Topics |
- Adult
- Aged
- CD8 Antigens
(metabolism)
- Epstein-Barr Virus Infections
(immunology, therapy, virology)
- Esophageal Neoplasms
(immunology, therapy, virology)
- Female
- Herpesvirus 4, Human
(genetics, isolation & purification)
- Humans
- Immunocompromised Host
- In Situ Hybridization
- Male
- Mediastinal Neoplasms
(immunology, therapy, virology)
- Middle Aged
- Nose Neoplasms
(immunology, therapy, virology)
- Plasmacytoma
(immunology, therapy, virology)
- Poly(A)-Binding Proteins
(metabolism)
- Prognosis
- RNA, Viral
(genetics)
- T-Cell Intracellular Antigen-1
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