[¹²³I]ICF01012 melanoma imaging and [¹³¹I]ICF01012 dosimetry allow adapted internal targeted radiotherapy in preclinical melanoma models.

Abstract

BACKGROUND:

Melanin-targeting radiotracers are interesting tools for imaging and treatment of pigmented melanoma metastases. However, variation of the pigment concentration may alter the efficiency of such targeting.

OBJECTIVES:

A clear assessment of both tumor melanin status and dosimetry are therefore prerequisites for internal radiotherapy of disseminated melanoma.

MATERIALS & METHODS:

The melanin tracer ICF01012 was labelled with iodine-123 for melanoma imaging in pigmented murine B16F0 and human SK-Mel 3 melanomas.

RESULTS:

In vivo imaging showed that the uptake of [(123)I]ICF01012 to melanomas correlated significantly with melanin content. Schedule treatment of 3 × 25 MBq [(131)I]ICF01012 significantly reduced SK-Mel 3 tumor growth and significantly increased the median survival in treated mice. For this protocol, the calculated delivered dose was 53.2 Gy.

CONCLUSION:

Radio-iodinated ICF01012 is a good candidate for both imaging and therapeutic purposes for patients with metastatic pigmented melanomas.

• Authors: Claire Viallard, Yann Perrot, Zied Boudhraa, Elodie Jouberton, Elisabeth Miot-Noirault, Mathilde Bonnet, Sophie Besse, Florence Mishellany, Anne Cayre, Lydia Maigne, Latifa Rbah-Vidal, Michel D'Incan, Florent Cachin, Jean-Michel Chezal, Françoise Degoul
• Journal: European journal of dermatology : EJD (Eur J Dermatol) 2015 Jan-Feb Vol. 25 Issue 1 Pg. 29-35 ISSN: 1952-4013 [Electronic] France
• PMID: 25548082 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Iodine Radioisotopes
• Melanins
• N-(2-diethylaminoethyl)-6-iodoquinoxaline-2-carboxamide
• Quinoxalines

Topics

• Animals
• Cell Line, Tumor
• Humans
• Iodine Radioisotopes
• Male
• Melanins (metabolism)
• Melanoma (diagnostic imaging, pathology, radiotherapy)
• Mice
• Mice, Nude
• Neoplasms, Experimental
• Quinoxalines
• Radiation Dosage
• Skin Neoplasms
• Tomography, Emission-Computed, Single-Photon (methods)