[Genetic polymorphisms of PDGFR associated with thrombocytopenia in Chinese patients with clear-cell metastatic renal cell carcinoma treated with sunitinib].

Abstract

OBJECTIVE:

To explore the genetic polymorphisms of PDGFR associated with thrombocytopenia in Chinese patients with metastatic clear-cell renal cell carcinoma (mcc-RCC) treated with sunitinib.

METHODS:

A total of 93 mcc-RCC patients treated with sunitinib were enrolled. Genotype analyses were performed before treatment and thrombocytopenia was recorded on the first three cycles of treatment. Genetic polymorphisms of PDGFR (rs35597368, rs1800810) were analyzed for a possible association with thrombocytopenia.

RESULTS:

The genotypes of rs35597368 and rs1800810 conformed to the Hardy-Weinberg law. No significant difference existed in grade 3/4 thrombocytopenia between rs35597368 TC and TT genotypes (29.6% vs 29.4%, P = 0.313). The rs1800810 CG genotype was associated with a higher risk for grade 3/4 thrombocytopenia as compared with CC genotype (45.8% vs 34.2%, P = 0.048).

CONCLUSIONS:

The risk for grade 3/4 thrombocytopenia increases in the presence of allele genotype in PDGFR 1171C/G. And a biomarker may be customized for patients with mcc-RCC treated with sunitinib.

• Authors: Xinan Sheng, Yan Kong, Huan Tang, Bin Lian, Lili Mao, Zhihong Chi, Chuanliang Cui, Lu Si, Xuan Wang, Xieqiao Yan, Siming Li, Jie Dai, Jun Guo
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 94 Issue 38 Pg. 2988-91 (Oct 21 2014) ISSN: 0376-2491 [Print] China
• PMID: 25547700 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Indoles
• Pyrroles
• Receptors, Platelet-Derived Growth Factor
• Sunitinib

Topics

• Antineoplastic Agents
• Asian People
• Carcinoma, Renal Cell
• Genotype
• Humans
• Indoles
• Polymorphism, Genetic
• Pyrroles
• Receptors, Platelet-Derived Growth Factor
• Sunitinib
• Thrombocytopenia
• Treatment Outcome