Safety and efficacy of lisinopril in elderly patients with mild to moderate hypertension.

Abstract

The safety and efficacy of once-daily lisinopril was assessed in an 8-week open-label study of 24 elderly patients with mild to moderate hypertension. Following withdrawal of all previous antihypertensive treatment, including diuretics, lisinopril treatment was started at a dose of 5 mg, increasing to a maximum of 40 mg once daily as required. Treatment provided effective 24-h BP control in all patients, most of whom required a daily dose of 20-40 mg, and cardiothoracic index decreased significantly, indicating a favourable effect on left ventricular volumes. There were no significant ECG alterations and no major side effects occurred. It is concluded that lisinopril 5 mg is a safe starting dose for elderly patients who are not on diuretics, and that once-daily lisinopril monotherapy reduces BP safety without affecting heart rate.

• Authors: R Marlier, P Vandepapelière, G De Vriese
• Journal: Journal of human hypertension (J Hum Hypertens) Vol. 3 Suppl 1 Pg. 163-7 (Jun 1989) ISSN: 0950-9240 [Print] England
• PMID: 2550639 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Enalapril
• Lisinopril

Topics

• Aged
• Aged, 80 and over
• Angiotensin-Converting Enzyme Inhibitors (adverse effects, therapeutic use)
• Blood Pressure (drug effects)
• Enalapril (adverse effects, analogs & derivatives, therapeutic use)
• Heart Rate (drug effects)
• Humans
• Hypertension (drug therapy)
• Lisinopril