Effect of Sex and Impaired Glucose Tolerance on Organ-Specific Dietary Fatty Acid Metabolism in Humans.

Abstract

Oral 14(R,S)-[(18)F]-fluoro-6-thia-heptadecanoic acid was used to determine whether an increase in cardiac dietary fatty acid (DFA) metabolism in impaired glucose tolerance (IGT) is different in men and women. Myocardial DFA partitioning after 6 h was higher in IGT versus control subjects (P = 0.006) in both men (2.14 [95% CI 1.70-2.18] vs. 1.28 standard uptake value [SUV] units [0.80-1.76]) and women (1.95 [1.57-2.33] vs. 1.64 SUV units [1.32-1.96]) without difference between sexes. Myocardial DFA fractional uptake (Ki) between time 90 and 120 min postprandially was also higher in IGT versus control subjects (P < 0.001) in men (0.063 [0.032-0.095] vs. 0.016 min(-1) [0.007-0.025]) and women (0.050 [0.024-0.077] vs. 0.030 min(-1) [0.013-0.047]) without significant sex difference. Men had higher net myocardial DFA uptake between time 90 and 120 min driven by higher chylomicron-triglyceride (TG) levels. IGT-associated increased cardiac DFA partitioning was directly related to obesity in women, whereas it was associated with IGT per se in men. We conclude that early cardiac DFA uptake is higher in men driven by change in postprandial chylomicron-TG level but that increase in 6-h postprandial cardiac DFA partitioning nevertheless occurs with IGT both in men and women.

• Authors: Margaret Kunach, Christophe Noll, Serge Phoenix, Brigitte Guérin, Jean-Patrice Baillargeon, Eric E Turcotte, André C Carpentier
• Journal: Diabetes (Diabetes) Vol. 64 Issue 7 Pg. 2432-41 (Jul 2015) ISSN: 1939-327X [Electronic] United States
• PMID: 25503741 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

Chemical References

• Fatty Acids
• Fluorine Radioisotopes
• 14-fluoro-6-thiaheptadecanoic acid

Topics

• Adipose Tissue (metabolism)
• Adult
• Fatty Acids (administration & dosage, metabolism)
• Female
• Fluorine Radioisotopes
• Glucose Intolerance (metabolism)
• Humans
• Insulin Resistance
• Male
• Middle Aged
• Myocardium (metabolism)
• Organ Specificity
• Positron-Emission Tomography
• Sex Characteristics
• Tomography, X-Ray Computed