Downregulation of Kruppel-like factor 2 is associated with poor prognosis for nonsmall-cell lung cancer.

Abstract

Kruppel-like factor 2 (KLF2) expression is diminished in many malignancies. However, its expression and role in nonsmall-cell lung cancer (NSCLC) remain unknown. In this study, we found that KLF2 levels were decreased in NSCLC tissues compared with adjacent normal tissues. Its expression level was significantly correlated with TNM stages, tumor size, and lymph node metastasis. Moreover, patients with low levels of KLF2 expression had a relatively poor prognosis. Furthermore, knockdown of KLF2 expression by siRNA could promote cell proliferation, while ectopic expression of KLF2 inhibited cell proliferation and promoted apoptosis in NSCLC cells partly via regulating CDKN1A/p21 and CDKN2B/p15 protein expression. Our findings present that decreased KLF2 could be identified as a poor prognostic biomarker in NSCLC and regulate cell proliferation and apoptosis.

• Authors: Li Yin, Ji-peng Wang, Tong-peng Xu, Wen-ming Chen, Ming-de Huang, Rui Xia, Xin-xin Liu, Rong Kong, Ming Sun, Er-bao Zhang, Yong-qian Shu
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 36 Issue 4 Pg. 3075-84 (Apr 2015) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 25501704 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• KLF2 protein, human
• Kruppel-Like Transcription Factors

Topics

• Adult
• Apoptosis (genetics)
• Carcinoma, Non-Small-Cell Lung (genetics, pathology)
• Cell Line, Tumor
• Cell Proliferation (genetics)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Kaplan-Meier Estimate
• Kruppel-Like Transcription Factors (biosynthesis, genetics)
• Lymphatic Metastasis
• Male
• Middle Aged
• Prognosis