Abstract | BACKGROUND: Small vessel disease (SVD) represents a common often progressive condition in elderly people contributing to cognitive disability. The relationship between cerebrospinal fluid (CSF) biomarkers and imaging correlates of SVD was investigated, and the findings were hypothesized to be associated with a neuropsychological profile of SVD. METHODS: RESULTS: The WMH volume correlated with ventricular dilation, which was associated with executive function and speed and attention. Increased WMH and ventricular dilation were related to increased CSF levels of TIMP-1, NF-L and MBP and to decreased sAPPβ. A positive correlation was found between the CSF biomarker MMP-9 and WMH progression. CONCLUSIONS: The link between progressive WMH and MMP-9 suggests an involvement of the enzyme in white matter degeneration. CSF TIMP-1, NF-L, MBP and sAPPβ may function as biological markers of white matter damage.
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Authors | Maria Bjerke, Michael Jonsson, Arto Nordlund, Carl Eckerström, Kaj Blennow, Henrik Zetterberg, Leonardo Pantoni, Domenico Inzitari, Reinhold Schmidt, Anders Wallin |
Journal | Dementia and geriatric cognitive disorders extra
(Dement Geriatr Cogn Dis Extra)
Vol. 4
Issue 3
Pg. 385-94
(Sep 2014)
ISSN: 1664-5464 [Print] Switzerland |
PMID | 25493088
(Publication Type: Journal Article)
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