Abstract | OBJECTIVE: MATERIALS AND METHODS: 28 male Wistar rats were divided into: 1) Control non-diabetic, 2) Streptozotocin (STZ)-induced diabetic rats (55 mg/kg, i.p.), 3) Control non-diabetic+ADM-52-22, and 4) STZ-diabetes+ADM-52-22 (7 per group). ADM-52-22 was infused for two weeks (250 µg/rat/day, i.p.). RESULTS: Diabetes caused an increase in kidney weight, renal VEGF levels, 24 hr urinary protein and nitric oxide excretion and hyperfiltration indicated by creatinine clearance (CrCl). ADM-22-52 reduced the rise in CrCl, total urinary protein and renal hypertrophy in diabetic rats, and attenuated early angiogenic response to diabetes: CD31 staining, flk1 protein and VEGF renal levels. CONCLUSIONS: These results show that AM through its receptor mediates early angiogenesis-induced diabetic nephropathy which attributes to the early changes as hyperfiltration and hypertrophy.
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Authors | E A El Eter, A A Al-Masri |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
Vol. 18
Issue 22
Pg. 3534-43
(Nov 2014)
ISSN: 2284-0729 [Electronic] Italy |
PMID | 25491634
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Adrenomedullin
- Vascular Endothelial Growth Factor A
- adrenomedullin receptor, rat
- Adrenomedullin
- Streptozocin
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Topics |
- Adrenomedullin
(physiology)
- Animals
- Diabetes Mellitus, Experimental
(metabolism, pathology)
- Diabetic Nephropathies
(etiology, metabolism, pathology)
- Kidney
(drug effects, metabolism, pathology)
- Male
- Neovascularization, Pathologic
(metabolism, pathology)
- Rats
- Rats, Wistar
- Receptors, Adrenomedullin
(antagonists & inhibitors, physiology)
- Streptozocin
- Vascular Endothelial Growth Factor A
(metabolism)
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