[Lipid formulations of amphotericin].

Abstract

Amphotericin B deoxycholate use has increased during the past years in parallel with the increase in the number of immunosuppressed patients suffering invasive fungal infections. This drug is associated with a high rate of side effects, especially renal toxicity. Lipid formulations (liposomal, lipid complex, colloidal suspension and the Indian liposomal formulation) have been developed, which share the same antifungal spectrum but differ in efficacy and toxicity. A review of amphotericin lipid formulations is presented, focusing on differences in efficacy and, especially renal toxicity. The main problem for use of these formulations in Latin America is their highcost.

• Authors: Martha C Botero, Marcela Puentes-Herrera, Jorge A Cortés
• Journal: Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia (Rev Chilena Infectol) Vol. 31 Issue 5 Pg. 518-27 (Oct 2014) ISSN: 0716-1018 [Print] Chile
• Vernacular Title: Formas lipídicas de anfotericina.
• PMID: 25491449 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Antifungal Agents
• Colloids
• Excipients
• Lipids
• Liposomes
• Amphotericin B

Topics

• Amphotericin B (adverse effects, chemistry)
• Antifungal Agents (adverse effects, chemistry)
• Colloids
• Excipients
• Humans
• Leishmaniasis (drug therapy)
• Lipids (chemistry)
• Liposomes
• Mycoses (drug therapy)