Abstract |
The previously published data on the association between CYP1A2*1C (rs2069514) and CYP1A2*1F (rs762551) polymorphisms and cancer risk have remained controversial. Hence, we performed a meta-analysis to investigate the association between CYP1A2*1F and CYP1A2*1C polymorphisms and cancer risk under different inheritance models. Overall, significant association was observed between CYP1A2*1F and cancer risk when all the eligible studies were pooled into the meta-analysis (dominant model: OR 1.08, 95 % CI 1.02-1.15; heterozygous model: OR 1.06, 95 % CI 1.01-1.12; additive model: OR 1.07, 95 % CI 1.02-1.13). In the further stratified and sensitivity analyses, for CYP1A2*1F polymorphism, significantly increased lung cancer risk and significantly decreased bladder cancer risk were observed in Caucasians. For CYP1A2*1C polymorphism, no significant association was found in overall and all subgroup analyses. In summary, this meta-analysis suggests that CYP1A2*1F polymorphism is associated with lung cancer and bladder cancer risk in Caucasians.
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Authors | Wen-Xia Sun, Ying-Hua Chen, Zhi-Zhong Liu, Jian-Jun Xie, Wei Wang, Ya-Ping Du, Yu Chen, Xu-Liang Shen, Xiao-Feng He, Li-Xia Wu, Wu Wei, Lin Zhang |
Journal | Molecular genetics and genomics : MGG
(Mol Genet Genomics)
Vol. 290
Issue 2
Pg. 709-25
(Apr 2015)
ISSN: 1617-4623 [Electronic] Germany |
PMID | 25472037
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
- CYP1A2 protein, human
- Cytochrome P-450 CYP1A2
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Topics |
- Case-Control Studies
- Cytochrome P-450 CYP1A2
(genetics)
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Lung Neoplasms
(genetics)
- Polymorphism, Single Nucleotide
- Risk
- Urinary Bladder Neoplasms
(genetics)
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