Abstract | PURPOSE: METHODS:
Tumor tissue, epidemiological, and clinical data were collected from 216 women with incident, primary, histologically confirmed breast cancer enrolled in the Roswell Park Cancer Institute (RPCI) Data Bank and BioRepository (DBBR). On average, three tumor cores from each participant were assembled into a tissue micro array. After immunohistochemical staining, a trained RPCI pathologist determined AR status of each core. Lignan intake was calculated from a food frequency questionnaire collected upon enrollment into the DBBR. RESULTS: We observed a weak positive association between dietary lignans and AR expression [β (SE) 27.6 (17.0), p 0.10], and there was no significant difference in lignan intake across categories of AR expression (p = 0.09, R (2) = 0.35). CONCLUSION: Our results do not support a clear relationship between dietary lignan intake and AR expression. This investigation is the first, to our knowledge, to examine dietary lignan intake and AR expression in breast tumors. Further research is needed within a larger, more representative sample to determine whether lignan intake is truly associated with AR expression.
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Authors | AnnaLynn M Williams, Matthew Bonner, Heather M Ochs-Balcom, Helena Hwang, Carl Morrison, Susan E McCann |
Journal | Cancer causes & control : CCC
(Cancer Causes Control)
Vol. 26
Issue 2
Pg. 311-317
(Feb 2015)
ISSN: 1573-7225 [Electronic] Netherlands |
PMID | 25471060
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- AR protein, human
- Androgens
- Lignans
- Phytoestrogens
- Receptors, Androgen
- Receptors, Estrogen
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Topics |
- Adult
- Aged
- Androgens
- Body Mass Index
- Breast Neoplasms
(etiology, prevention & control)
- Diet
- Feeding Behavior
- Female
- Humans
- Immunohistochemistry
(methods)
- Lignans
(chemistry)
- Middle Aged
- Phytoestrogens
- Receptors, Androgen
(biosynthesis)
- Receptors, Estrogen
(metabolism)
- Tissue Array Analysis
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