Abstract | BACKGROUND AND PURPOSE: METHODS AND MATERIALS: Between February 2002 and March 2012, 80 patients were treated with proton therapy (PT) or carbon ion therapy ( CIT) alone. PT and CIT were employed in 40 (50%) patients each, and more than half of the patients received 65.0 GyE in 26 fractions (n=47, 59%). RESULTS: The median duration of follow-up was 38 months (range, 6-115 months). For all patients, the 5-year for overall survival (OS) rate, progression-free survival (PFS) rate, and local control (LC) rate were 63%, 39%, and 75%, respectively. No significant differences between PT and CIT were observed. The 5-year LC rates for T4 and inoperable cases were 66% and 68%, respectively. Twenty-one patients (26%) experienced grade 3 or greater late toxicities, including three patients who developed grade 5 bleeding from nasopharyngeal ulcers. CONCLUSIONS: Particle radiotherapy for ACC achieves favourable LC, and its efficacy in inoperable or T4 cases is promising. There were no significant differences between PT and CIT in terms of OS, PFS and LC.
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Authors | Masaru Takagi, Yusuke Demizu, Naoki Hashimoto, Masayuki Mima, Kazuki Terashima, Osamu Fujii, Dongcun Jin, Yasue Niwa, Koichi Morimoto, Takashi Akagi, Takashi Daimon, Ryohei Sasaki, Yoshio Hishikawa, Mitsuyuki Abe, Masao Murakami, Nobukazu Fuwa |
Journal | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
(Radiother Oncol)
Vol. 113
Issue 3
Pg. 364-70
(Dec 2014)
ISSN: 1879-0887 [Electronic] Ireland |
PMID | 25467004
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Adenoid Cystic
(mortality, radiotherapy)
- Disease-Free Survival
- Female
- Head and Neck Neoplasms
(mortality, radiotherapy)
- Heavy Ion Radiotherapy
(methods)
- Humans
- Ions
(therapeutic use)
- Male
- Middle Aged
- Proton Therapy
- Retrospective Studies
- Survival Rate
- Treatment Outcome
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