Evaluation of anti-colitic effect of fluvoxamine against acetic acid-induced colitis in normal and reserpinized depressed rats.

Abstract

High prevalence of psychological comorbidities such as depression and anxiety in patients with inflammatory bowel disease (IBD) supports the premise that adding an anti-depressant drug with known anti-inflammatory effect to the medical treatment have beneficial effect in the course of the underlying disease. Colitis was induced by intracolonic instillation of 2 ml of 4% v/v acetic acid solution in rats. Anti-colitic effect of fluvoxamine was evaluated in two categories: A: normal rats, B: reserpinized (6 mg/kg, i.p.) depressed rats. In group A, fluvoxamine (2.5, 5, 10 mg/kg, i.p.) was administered 2 h after induction of colitis and in group B: reserpine (6 mg/kg, i.p.) was administered 1 h prior to colitis induction and then fluvoxamine (2.5, 5, 10 mg/kg, i.p.) was administered 2 h after colitis induction. Dexamethasone (1 mg/kg) was used as reference drug. All the treatments continued daily for five days. The effect was assessed on the basis of macroscopic score, biochemical (myeloperoxidase) changes and histopathological studies. Results showed that fluvoxamine (2.5 and 5 mg/kg) and dexamethasone treatment markedly reduced disease severity in both reserpinized and non-reserpinized rats as indicated by reduction in macroscopic and microscopic colonic damages while reserpine adversely exacerbated the colitis damage. Myeloperoxidase activity which was increased following colitis induction was also decreased. The findings of this study elucidate the anti-colitic and anti-inflammatory properties of fluvoxamine and so introduced it as a good candidate to treat depressive symptoms in people comorbid to IBD.

• Authors: Mohsen Minaiyan, Valiollah Hajhashemi, Mohammad Rabbani, Ehsan Fattahian, Parvin Mahzouni
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 746 Pg. 293-300 (Jan 05 2015) ISSN: 1879-0712 [Electronic] Netherlands
• PMID: 25460023 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antidepressive Agents, Second-Generation
• Antipsychotic Agents
• Gastrointestinal Agents
• Dexamethasone
• Reserpine
• Peroxidase
• Fluvoxamine

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, adverse effects, therapeutic use)
• Antidepressive Agents, Second-Generation (administration & dosage, therapeutic use)
• Antipsychotic Agents (administration & dosage, adverse effects, therapeutic use)
• Colitis, Ulcerative (drug therapy, immunology, pathology, psychology)
• Colon (drug effects, enzymology, immunology, pathology)
• Depression (complications, drug therapy)
• Dexamethasone (therapeutic use)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Drug Resistance
• Fluvoxamine (administration & dosage, adverse effects, therapeutic use)
• Gastrointestinal Agents (administration & dosage, adverse effects, therapeutic use)
• Intestinal Mucosa (drug effects, enzymology, immunology, pathology)
• Male
• Neutrophil Infiltration
• Peroxidase (antagonists & inhibitors, chemistry, metabolism)
• Random Allocation
• Rats, Wistar
• Reserpine (administration & dosage, adverse effects, therapeutic use)