Abstract |
Aging is associated with a variety of physiological changes originating peripherally and centrally, including within the autonomic nervous system. Sleep-wake disturbances constitute reliable hallmarks of aging in several animal species and humans. Recent studies have been interested in N-acetylmannosamine (ManNAc) a potential therapeutic agent for improving quality of life, as well as preventing age-related cognitive decline. In this study, ManNAc (5.0 mg/ml) was administered in the drinking water of middle-aged male C57BL/6J mice (55 weeks old) for 7 days. Mice were housed under a 12:12 h light:dark cycle at 23-24 °C. We evaluated bio-behavioral activity using electrocardiogram, body temperature and locomotor activity recorded by an implanted telemetry transmitter. To estimate sleep-wake profile, surface electroencephalogram and electromyogram leads connected to a telemetry transmitter were also implanted in mice. Autonomic nervous activity was evaluated using power spectral analysis of heart rate variability. ManNAc-treated mice spent more time in a wakeful state and less time in slow wave sleep during the dark phase. Parasympathetic nervous activity was increased following ManNAc treatment, then the sympatho-vagal balance was shifted predominance of parasympathetic nervous system. Furthermore, improvement in sleep-wake pattern was associated with increased parasympathetic nervous activity. These results suggest that ManNAc treatment can improve bio-behavioral activity and sleep-wake quality in middle-aged mice. This may have implications for improving sleep patterns in elderly humans.
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Authors | Masayoshi Kuwahara, Koichi Ito, Koji Hayakawa, Shintaro Yagi, Kunio Shiota |
Journal | Autonomic neuroscience : basic & clinical
(Auton Neurosci)
Vol. 187
Pg. 56-62
(Jan 2015)
ISSN: 1872-7484 [Electronic] Netherlands |
PMID | 25443216
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier B.V. All rights reserved. |
Chemical References |
- Hexosamines
- N-acetylmannosamine
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Topics |
- Aging
- Animals
- Autonomic Nervous System
(drug effects, physiology)
- Blood Pressure
(drug effects)
- Body Temperature
(drug effects)
- Brain Waves
(drug effects)
- Electrocardiography
- Electroencephalography
- Electromyography
- Fourier Analysis
- Heart Rate
(drug effects)
- Hexosamines
(pharmacology)
- Male
- Mice
- Mice, Inbred C57BL
- Motor Activity
(drug effects)
- Sleep
(drug effects)
- Statistics as Topic
- Telemetry
- Wakefulness
(drug effects)
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