Abstract | BACKGROUND: Several studies have reported an association between use of over-the-counter antipyretics during pregnancy or infancy and increased asthma risk. An important potential limitation of these observational studies is confounding by indication. OBJECTIVES: METHODS: We included 1490 mother-child pairs in Project Viva, a longitudinal prebirth cohort study. We categorized prenatal acetaminophen exposure as the maximum intake (never, 1-9 times, or ≥10 times) in early pregnancy or midpregnancy and ibuprofen intake as presence or absence in early pregnancy. We expressed intake of antipyretics in infancy as never, 1 to 5 times, 6 to 10 times, or more than 10 times. We examined the associations of acetaminophen and ibuprofen (per unit increase in exposure category) during pregnancy and infancy with wheeze, asthma, and allergen sensitization in early childhood (3-5 years of age, n = 1419) and midchildhood (7-10 years of age, n = 1220). RESULTS: CONCLUSIONS:
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Authors | Joanne E Sordillo, Christina V Scirica, Sheryl L Rifas-Shiman, Matthew W Gillman, Supinda Bunyavanich, Carlos A Camargo Jr, Scott T Weiss, Diane R Gold, Augusto A Litonjua |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 135
Issue 2
Pg. 441-8
(Feb 2015)
ISSN: 1097-6825 [Electronic] United States |
PMID | 25441647
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents, Non-Steroidal
- Acetaminophen
- Ibuprofen
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Topics |
- Acetaminophen
(adverse effects)
- Adult
- Analgesics, Non-Narcotic
(adverse effects)
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects)
- Asthma
(etiology)
- Child
- Child, Preschool
- Female
- Humans
- Ibuprofen
(adverse effects)
- Infant
- Infant, Newborn
- Male
- Patient Outcome Assessment
- Pregnancy
- Prenatal Exposure Delayed Effects
(epidemiology)
- Respiratory Sounds
(etiology)
- Risk
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