Assessment of ototoxicity of tea tree oil in a chinchilla animal model.

Abstract

OBJECTIVE:

The aim of the present study is to examine the effects of tea tree oil on hearing function and cochlear morphology after intratympanic administration in a chinchilla animal model.

METHODS:

Nine chinchillas received intratympanic injection of 3% tea tree oil dissolved in olive oil in one ear, whereas the contralateral control ear received olive oil only. Outcome measures included auditory brainstem responses conducted before treatment and at 10 days and 30 days following the injection. Post-mortem cochlear morphology was assessed using scanning electron microscopy.

RESULTS:

At 10 and 30 days following the injection, there was no significant change in auditory brain response thresholds at 8, 16, 20 or 25kHz. Scanning electron microscopy imaging showed no damage to auditory hair cells.

CONCLUSION:

Tea tree oil (3%) does not appear to be ototoxic in a chinchilla animal model. Future preclinical and clinical studies are required to establish the effectiveness of TTO in treating otitis.

• Authors: Aren Bezdjian, Mario A Mujica-Mota, Michelle Azzi, Sam J Daniel
• Journal: International journal of pediatric otorhinolaryngology (Int J Pediatr Otorhinolaryngol) Vol. 78 Issue 12 Pg. 2136-9 (Dec 2014) ISSN: 1872-8464 [Electronic] Ireland
• PMID: 25441606 (Publication Type: Journal Article)
• Copyright: Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Anti-Infective Agents, Local
• Tea Tree Oil

Topics

• Animals
• Anti-Infective Agents, Local (pharmacology)
• Auditory Threshold (drug effects)
• Chinchilla
• Cochlea (drug effects, pathology)
• Evoked Potentials, Auditory, Brain Stem (drug effects)
• Hair Cells, Auditory (drug effects, pathology)
• Injection, Intratympanic
• Microscopy, Electron, Scanning
• Models, Animal
• Tea Tree Oil (pharmacology)