Interaction of DRD2TaqI, COMT, and ALDH2 genes associated with bipolar II disorder comorbid with anxiety disorders in Han Chinese in Taiwan.

Abstract

It is hypothesized that dopaminergic genes-dopamine type-2 receptor (DRD2), aldehyde dehydrogenase 2 (ALDH2), and catechol-O-methyltransferase (COMT)-are associated with bipolar disorder (BP) and anxiety disorder (AD). Bipolar II (BP-II) is reported to be highly comorbid with AD. We examined whether interactions among these three genes are susceptibility factors in BP-II with AD (BP-II(+AD)) and without AD (BP-II(-AD)). In this study, we hypothesize that the interaction of the dopaminergic genes between BP-II(+AD) and BP-II(-AD) is significant different. We recruited 1260 participants: 495 with BP-II(-AD), 170 with BP-II(+AD), and 595 healthy controls without BP-II or AD. Genotyping was done using polymerase chain reactions plus restriction fragment length polymorphism analysis. Genotypic frequencies of the DRD2TaqIA, COMT, and ALDH2 polymorphisms between the two BP-II groups were nonsignificant. In logistic regression, the ALDH2 and DRD2TaqIA genes showed a main effect that was protective against BP-II(-AD) (odds ratio [OR] = 0.497, p = 0.010, and OR = 0.415, p = 0.017, respectively). The interaction of DRD2TaqIA A1/A1 and ALDH2*1/*1 had a significant risk effect on the BP-II(-AD) group (OR = 7.177, p < 0.001). However, the interaction of DRD2TaqIA A1/A1, ALDH2*1/*1, and COMTMet/Met&Val/Met become a weak protective factor against BP-II(-AD) (OR = 0.205, p = 0.047). All of the significant results described above are found only in BP-II(-AD). This study supports the hypothesis the interaction of the dopaminergic genes between BP-II(+AD) and BP-II(-AD) is significant different,, and provides additional evidence that the DRD2TaqIA A1/A1, ALDH2*1/*1 and COMT genes interact in BP-II(-AD) but not in BP-II(+AD).

• Authors: Ming-Chuan Hu, Sheng-Yu Lee, Tzu-Yun Wang, Yun-Hsuan Chang, Shiou-Lan Chen, Shih-Heng Chen, Chun-Hsien Chu, Chen-Lin Wang, I Hui Lee, Po See Chen, Yen Kuang Yang, Ru-Band Lu
• Journal: Metabolic brain disease (Metab Brain Dis) Vol. 30 Issue 3 Pg. 755-65 (Jun 2015) ISSN: 1573-7365 [Electronic] United States
• PMID: 25430946 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DRD2 protein, human
• Receptors, Dopamine D2
• ALDH2 protein, human
• Aldehyde Dehydrogenase
• Aldehyde Dehydrogenase, Mitochondrial
• COMT protein, human
• Catechol O-Methyltransferase

Topics

• Adult
• Aldehyde Dehydrogenase (genetics)
• Aldehyde Dehydrogenase, Mitochondrial
• Anxiety Disorders (diagnosis, epidemiology, genetics)
• Asian People (genetics)
• Bipolar Disorder (diagnosis, epidemiology, genetics)
• Catechol O-Methyltransferase (genetics)
• Comorbidity
• Epistasis, Genetic (genetics)
• Female
• Humans
• Male
• Middle Aged
• Receptors, Dopamine D2 (genetics)
• Taiwan (epidemiology)
• Young Adult