Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: A growing number of studies in animal models and human diseases have shown that DPP-4 inhibition ameliorates kidney disease by a process independent of glucose lowering. Possible mechanisms underlying such protective properties include the facilitation of natriuresis and reduction of blood pressure, and also local effects of the reduction of oxidative stress, inflammation and improvement of endothelial function in the kidney. DPP-4 inhibitors may also restore other DPP-4 substrates which have proven renal effects. SUMMARY: Treatment of diabetes with DPP-4 inhibitors is likely to involve a variety of extrapancreatic effects including renal protection. Such pleiotropic action of DPP-4 inhibitors might occur by both incretin-dependent and incretin-independent mechanisms. Conclusive evidence is needed to translate the favorable results from animal models to humans.
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Authors | Yuichi Makino, Yukihiro Fujita, Masakazu Haneda |
Journal | Current opinion in nephrology and hypertension
(Curr Opin Nephrol Hypertens)
Vol. 24
Issue 1
Pg. 67-73
(Jan 2015)
ISSN: 1473-6543 [Electronic] England |
PMID | 25415611
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Dipeptidyl-Peptidase IV Inhibitors
- Incretins
- Gastric Inhibitory Polypeptide
- Glucagon-Like Peptide 1
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Topics |
- Animals
- Diabetic Nephropathies
(drug therapy, enzymology)
- Dipeptidyl-Peptidase IV Inhibitors
(therapeutic use)
- Gastric Inhibitory Polypeptide
(metabolism)
- Glucagon-Like Peptide 1
(metabolism)
- Humans
- Incretins
(metabolism)
- Kidney
(drug effects, enzymology)
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