More than half of pregnant women suffer from
nausea and
vomiting, in 0.5-1% of the pregnant women, if
nausea and
vomiting are severe and persistent, condition can progress to hyperemesis. We evaluated the fluid volume parameters in pregnant women with
hyperemesis gravidarum, before and
after treatment using the bioelectrical impedance vectors. A total of 70 pregnant women who had
weight loss exceeding 5% of pre-pregnancy
body weight were recruited for the study in the first trimester. The measurement of multi-frequency bioelectrical impedance analysis parameters was performed on the day of hospitalisation before any treatment and
after treatment at 24 h and 72 h with the same procedure. Total body water, extracellular water, intracellular water, and fat-free mass index increased
after treatment at 24 h (P < 0.01). Also, the mean pregnancy-unique quantification of
emesis and
nausea score was significantly lower
after treatment (11.3 ± 2.1 at enrolment, 5.1 ± 1.4 at 24 h and 4.3 ± 1.1 at 72 h) (P < 0.01), which correlated with the patients' clinical improvement and changes in hydration. In pregnant women with moderate-to-severe
hyperemesis gravidarum, significant body composition changes occur and fluid replacement
therapy performed during a short period of time, such as 24 h, provides improvement in body composition.