Abstract | BACKGROUND: The development of effective treatments against metastatic cancers, including breast cancer, is among the most important challenges in current experimental and clinical cancer research. We recently demonstrated that Walterinnesia aegyptia venom (WEV), either alone or in combination with silica nanoparticles (WEV+NP), resulted in the growth arrest and apoptosis of different cancer cell lines. AIMS: In the present study, we evaluated the impact of WEV alone and WEV+NP on human breast cancer cells isolated from cancer biopsies. METHODS: The potential effects of WEV alone and WEV+NP on the proliferation, induction of apoptosis and generation of free radicals in breast cancer cells isolated from 80 patients clinically diagnosed with breast cancer were evaluated by flow cytometry and ELISA. RESULTS: CONCLUSION: Our data indicate the therapeutic potential of the nanoparticle-sustained delivery of snake venom for the treatment of breast cancer.
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Authors | Gamal Badr, Douaa Sayed, Doaa Maximous, Amany O Mohamed, Mustafa Gul |
Journal | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
(Cell Physiol Biochem)
Vol. 34
Issue 5
Pg. 1640-51
( 2014)
ISSN: 1421-9778 [Electronic] Germany |
PMID | 25401286
(Publication Type: Journal Article)
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Copyright | © 2014 S. Karger AG, Basel. |
Chemical References |
- Reactive Oxygen Species
- Snake Venoms
- Silicon Dioxide
- Caspases
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Topics |
- Apoptosis
(drug effects)
- Breast Neoplasms
(drug therapy, metabolism)
- Caspases
(metabolism)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Female
- Humans
- Nanoparticles
(administration & dosage)
- Reactive Oxygen Species
(metabolism)
- Silicon Dioxide
(administration & dosage)
- Snake Venoms
(pharmacology)
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