First-trimester combined screening for trisomy 21 in women with renal disease.

Abstract

OBJECTIVE:

To evaluate the results of first-trimester combined screening for Down syndrome in women with chronic renal disease.

METHOD:

Fifty-five pregnant women with renal disease were compared with 110 patients matched for maternal age, maternal weight, smoking status, and gestational age. Maternal renal function was assayed at the time of the combined screening, and renal insufficiency was defined by serum creatinine >90 µmol/L and renal clearance <80 mL/min. We defined three groups: kidney disease and normal renal function (group 1), kidney disease and renal insufficiency (group 2), and a control group (group 3). The values of nuchal translucency, pregnancy-associated plasma protein A, human β-chorionic gonadotrophin (hCGβ), and false-positive rates for Down syndrome screening were compared.

RESULTS:

There were 39 (71%) and 16 (29%) cases in groups 1 and 2, respectively. Nuchal translucency and multiple of the median (MoM) pregnancy-associated plasma protein A were similar in the three groups. However, MoM hCGβ levels were higher in group 2 than in groups 1 and 3 (5.37 vs 1.1 vs 0.98 MoM, p = 0.0001). The resulting screen-positive rate was also higher in group 2 than in groups 1 and 3 (43.7% vs 10.2% vs 5.5%, p = 0.0001).

CONCLUSION:

Trisomy 21 first-trimester screening using hCGβ is not suitable in the case of maternal renal failure. © 2014 John Wiley & Sons, Ltd.

• Authors: Morgane Valentin, Françoise Muller, Marie Paule Beaujard, Sophie Dreux, Isabelle Czerkiewicz, Valérie Meyer, Marianne Leruez, Yves Ville, Laurent J Salomon
• Journal: Prenatal diagnosis (Prenat Diagn) Vol. 35 Issue 3 Pg. 244-8 (Mar 2015) ISSN: 1097-0223 [Electronic] England
• PMID: 25395363 (Publication Type: Journal Article)
• Copyright: © 2014 John Wiley & Sons, Ltd.

Chemical References

• Biomarkers
• Chorionic Gonadotropin, beta Subunit, Human
• Creatinine
• Pregnancy-Associated Plasma Protein-A
• PAPPA protein, human

Topics

• Adult
• Biomarkers (metabolism)
• Case-Control Studies
• Chorionic Gonadotropin, beta Subunit, Human (metabolism)
• Cohort Studies
• Creatinine (metabolism)
• Down Syndrome (blood, diagnosis, diagnostic imaging)
• False Positive Reactions
• Female
• Gestational Age
• Humans
• Maternal Age
• Nuchal Translucency Measurement
• Pregnancy
• Pregnancy Complications (metabolism)
• Pregnancy Trimester, First
• Pregnancy-Associated Plasma Protein-A (metabolism)
• Prenatal Diagnosis
• Renal Insufficiency, Chronic (metabolism)
• Retrospective Studies
• Ultrasonography, Prenatal
• Young Adult