Nanotheragnostic applications for ischemic and hemorrhagic strokes: improved delivery for a better prognosis.

Abstract

Stroke is the second leading cause of death worldwide and a major cause of long-term severe disability representing a global health burden and one of the highly researched medical conditions. Nanostructured material synthesis and engineering have been recently developed and have been largely integrated into many fields including medicine. Recent studies have shown that nanoparticles might be a valuable tool in stroke. Different types, shapes, and sizes of nanoparticles have been used for molecular/biomarker profiling and imaging to help in early diagnosis and prevention of stroke and for drug/RNA delivery for improved treatment and neuroprotection. However, these promising applications have limitations, including cytotoxicity, which hindered their adoption into clinical use. Future research is warranted to fully develop and effectively and safely translate nanoparticles for stroke diagnosis and treatment into the clinic. This work will discuss the emerging role of nanotheragnostics in stroke diagnosis and treatment applications.

• Authors: Tarek H Mouhieddine, Muhieddine M Itani, Amaly Nokkari, Changhong Ren, Georges Daoud, Asad Zeidan, Stefania Mondello, Firas H Kobeissy
• Journal: Current neurology and neuroscience reports (Curr Neurol Neurosci Rep) Vol. 15 Issue 1 Pg. 505 (Jan 2015) ISSN: 1534-6293 [Electronic] United States
• PMID: 25394858 (Publication Type: Journal Article, Review)

Chemical References

• Neuroprotective Agents

Topics

• Animals
• Brain Ischemia (diagnosis, drug therapy, pathology, physiopathology)
• Drug Delivery Systems
• Humans
• Intracranial Hemorrhages (diagnosis, drug therapy, pathology, physiopathology)
• Nanoparticles (adverse effects, therapeutic use)
• Neuroprotective Agents (administration & dosage)
• Prognosis
• Stroke (diagnosis, drug therapy, pathology, physiopathology)