Abstract | CONTEXT: OBJECTIVE: The objective of the study was to compare the serum levels of sex steroids, precursors, and metabolites between men with complete IHH and those with Hypo-Pit. PATIENTS: METHODS: Gas chromatography/mass spectrometry (GCMS) was used to measure the serum levels of sex steroids [T, dihydrotestosterone (DHT), and estradiol (E2)], their precursors ( pregnenolone, 17-hydroxypregnenolone, dehydroepiandrosterone, androstenediol, progesterone, 17-hydroxyprogesterone, and androstenedione), and their metabolites ( androsterone, estrone, and estrone sulfate) as well as pregnenolone and dehydroepiandrosterone sulfate esters. RESULTS: All the above-mentioned steroids, and notably T, DHT, and E2, were significantly lower in IHH patients than in controls but remained well above the detection limit of the relevant assays. In Hypo-Pit men, all these steroids were dramatically and significantly lower than in IHH. Interestingly, T, DHT, and E2, as well as pregnenolone and dehydroepiandrosterone sulfate esters, were undetectable or barely detectable in the Hypo-Pit men. CONCLUSIONS:
Steroid deficiencies are marked but partial in men with complete IHH. In contrast, men with Hypo-Pit have a very severe overall steroid deficiency. These deficiencies could affect health and quality of life.
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Authors | Frank Giton, Séverine Trabado, Luigi Maione, Julie Sarfati, Yves Le Bouc, Sylvie Brailly-Tabard, Jean Fiet, Jacques Young |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 100
Issue 2
Pg. E292-6
(Feb 2015)
ISSN: 1945-7197 [Electronic] United States |
PMID | 25393641
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dihydrotestosterone
- Estrone
- Testosterone
- Androstenedione
- Dehydroepiandrosterone
- Progesterone
- Estradiol
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Topics |
- Adult
- Androstenedione
(blood)
- Chromatography, Gas
- Dehydroepiandrosterone
(blood)
- Dihydrotestosterone
(blood)
- Estradiol
(blood)
- Estrone
(blood)
- Humans
- Hypogonadism
(blood, drug therapy)
- Hypopituitarism
(blood, drug therapy)
- Male
- Mass Spectrometry
- Progesterone
(blood)
- Testosterone
(blood)
- Young Adult
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