Photodynamic therapy and vitrectomy for a large optic nerve hemangioma with neovascularization and retinal detachment: a clinicopathologic correlation.

Abstract

PURPOSE:

To report the clinicopathologic correlation of a young man with a von Hippel-Lindau disease-associated peripapillary hemangioblastoma and its satisfactory response to a combination of photodynamic therapy (PDT) and vitrectomy.

DESIGN:

Clinicopathologic correlation.

METHODS:

We studied the case of a 14-year-old boy with an optic nerve mass and large inferior exudative retinal detachment complicated by a significant tractional component from extensive secondary neovascularization over the lesion.

RESULTS:

A juxtapapillary hemangioblastoma with secondary neovascularization was documented by clinical examination, fundus photography, and optical coherence tomography. A von Hippel-Lindau gene mutation was detected. The patient responded satisfactorily to a combination of PDT and vitrectomy.

CONCLUSIONS:

A staged approach to treatment of peripapillary hemangioblastoma with a combination of PDT and vitrectomy may be favorable to therapy with one modality.

• Authors: Armando Alegret, Colleen M Cebulla, Sander R Dubovy, Lejla Mutapcic, Ditte J Hess, Timothy G Murray
• Journal: Retinal cases & brief reports (Retin Cases Brief Rep) Vol. 3 Issue 1 Pg. 93-5 ( 2009) ISSN: 1935-1089 [Print] United States
• PMID: 25390852 (Publication Type: Journal Article)