Abstract | BACKGROUND: METHODS: Thirty-two nonsmoking asthmatics with HDM allergy were treated with run-in medication ( fluticasone propionate 100 μg bid) during 2 weeks before the study day. All patients underwent bronchial challenge with HDM, and half of them were randomized to receive additional LPS. Both groups were randomized to receive pretreatment with a single inhalation of 100 μg salmeterol 30 min before bronchial segmental challenge. Six hours later, bronchoalveolar lavage (BAL) was collected for leukocyte cell count, differentials, and cellular activation markers. RESULTS: Challenge with HDM/LPS induced a significant increase in eosinophil cationic protein (P = 0.036) and a trend toward an increase in BALF eosinophils as compared to HDM challenge. CONCLUSION:
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Authors | M Berger, J D de Boer, P Bresser, T van der Poll, R Lutter, P J Sterk, J S van der Zee |
Journal | Allergy
(Allergy)
Vol. 70
Issue 3
Pg. 257-64
(Mar 2015)
ISSN: 1398-9995 [Electronic] Denmark |
PMID | 25381858
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Adrenal Cortex Hormones
- Allergens
- Bronchodilator Agents
- Lipopolysaccharides
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Topics |
- Administration, Inhalation
- Adrenal Cortex Hormones
(administration & dosage)
- Adult
- Allergens
(immunology)
- Animals
- Asthma
(diagnosis, drug therapy, immunology)
- Bronchodilator Agents
(administration & dosage)
- Eosinophils
(immunology, metabolism)
- Female
- Humans
- Inflammation
(drug therapy, immunology)
- Lipopolysaccharides
(immunology)
- Male
- Pyroglyphidae
(immunology)
- Treatment Outcome
- Young Adult
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