An unusual case of splenomegaly and increased lactate dehydrogenase heralding acute myeloid leukemia with eosinophilia and RUNX1-MECOM fusion transcripts.

Abstract

We report the first case of acute myeloid leukemia (AML) with RUNX1-MECOM fusion transcripts, showing marked eosinophilia. A 63-year old man admitted in August 2013, had previously been observed in April 2013, because of persisting homogeneous splenomegaly and increased LDH, which were initially attributed to both minor β-thalassemia and previous acute myocardial infarction. However, based upon the retrospective analysis of clinical features combined with the documentation of both JAK2 V617F and c-KIT D816V mutations at AML diagnosis, an aggressive leukemic transformation with eosinophilia of a previously unrecognized myeloproliferative neoplasm, rather than the occurrence of de novo AML, may be hypothesized.

• Authors: Fabio Forghieri, Sara Bigliardi, Monica Morselli, Leonardo Potenza, Valeria Fantuzzi, Laura Faglioni, Vincenzo Nasillo, Andrea Messerotti, Ambra Paolini, Mario Luppi
• Journal: Leukemia research reports (Leuk Res Rep) Vol. 3 Issue 2 Pg. 83-5 ( 2014) ISSN: 2213-0489 [Print] England
• PMID: 25379409 (Publication Type: Journal Article)