Solid
tumors, beyond mere accumulation of
cancer cells, form a complex ecosystem consisting of normal epithelial cells, fibroblasts, blood and lymphatic vessels, structural components, and infiltrating hematopoietic cells including myeloid and lymphoid elements that impact
tumor growth,
tumor spreading, and clinical outcome. The composition of the immune microenvironment is diverse, including various populations of T cells, B cells, dendritic cells, natural killer cells, myeloid-derived suppressor cells, neutrophils, or macrophages. The immune contexture describes the density, location, and organization of these immune cells within solid
tumors. In
lung cancer, which is the deadliest type of
cancer, and particularly in
non-small cell lung cancer, its most prevalent form, reports have described some of the interactions between the
tumor and the host. These data, in addition to articles on various types of
tumors, provide a greater understanding of the
tumor-host microenvironment interaction and stimulate the development of prognostic and predictive
biomarkers, the identification of novel target
antigens for therapeutic intervention, and the implementation of tools for long-term management of patients with
cancer.