Vigna angularis water extracts protect against ultraviolet b-exposed skin aging in vitro and in vivo.

Abstract

Exposure to ultraviolet (UV) radiation induces various pathological changes, such as thickened skin and wrinkle formation. In particular, UVB irradiation increases matrix metalloproteinase (MMP)-1 production and collagen degradation, leading to premature aging, termed photoaging. The azuki bean (Vigna angularis; VA) has been widely used as a food product as well as a traditional medicine. However, its activity needs additional study to confirm its functional application in foods and cosmetics for protecting skin. In this study, hot-water extract from VA (VAE) and its active component, rutin, were investigated to determine their antiphotoaging effects. VAE was found to have antioxidant activity. In UVB-exposed normal human dermal fibroblasts cells with VAE and rutin treatments, MMP-1 production was significantly suppressed (90% and 47%, respectively). The effects of both topical and oral administration of VAE were tested in UVB-irradiated hairless mice. VAE suppressed wrinkle formation and skin thickness by promoting elastin, procollagen type I, and TGF-β1 expression (118%, 156%, and 136%, respectively) and by diminishing MMP-1 production. These results suggest that VAE may be effective for preventing skin photoaging accelerated by UVB radiation.

• Authors: Eunson Hwang, Sang-Yong Park, Hyun Ji Lee, Zheng-wang Sun, Tae Youp Lee, Hyun Geun Song, Heon-Sub Shin, Tae Hoo Yi
• Journal: Journal of medicinal food (J Med Food) Vol. 17 Issue 12 Pg. 1339-49 (Dec 2014) ISSN: 1557-7600 [Electronic] United States
• PMID: 25369199 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Collagen Type I
• Plant Extracts
• Protective Agents
• Transforming Growth Factor beta1
• Water
• Elastin
• Matrix Metalloproteinase 1

Topics

• Animals
• Collagen Type I (metabolism, radiation effects)
• Elastin (drug effects)
• Fabaceae (chemistry)
• Humans
• In Vitro Techniques
• Male
• Matrix Metalloproteinase 1 (metabolism)
• Mice
• Mice, Hairless
• Plant Extracts (pharmacology)
• Protective Agents (administration & dosage, pharmacology)
• Skin (drug effects, radiation effects)
• Skin Aging (drug effects)
• Transforming Growth Factor beta1 (metabolism, radiation effects)
• Ultraviolet Rays (adverse effects)
• Water