The aim of this study was to evaluate, clinically and histologically, the influence of
laser and LED
photobiomodulation in the healing of
formocresol-induced oral mucosa
ulcers of rats. We used 60 Wistar rats in which
oral ulcers were induced on the gingiva of the lower incisors. Forty-eight hours after inducing the
ulcers, the animals were divided into three groups:
laser, LED, and untreated. Animals from the
laser group received irradiation with GaAlAs, 660 nm, CW, 40 mW, φ 4 mm(2), 4.8 J/cm(2). Animals from the LED group received irradiation with InGaAIP, 630 nm, 150 mW, 4.8 J/cm(2), 0.8 cm spot. Forty-eight hours after
oral ulcer induction, both irradiations were applied in a punctuate manner in the center of the
ulcer at 48-h interval until the end of the experimental period. The animals were killed at 3, 5, 7, and 11 days after day 0. The results of the clinical evaluation showed that the
laser and LED
phototherapies were able to accelerate the healing of
formocresol-induced
oral ulcers, which occurred first in the
laser group (ANOVA, p < 0.05). Histologically, there was a slight variation between LED and
laser therapy; therefore, the
laser group proved to be effective in accelerating wound healing, especially at 5 days, whereas the LED group was more effective at the end of the experimental period. It was concluded that
laser and LED
photobiomodulation were effective in accelerating the healing of
formocresol-induced
oral ulcers in both clinical and histological aspects.