Abstract |
The frequency of chromosome aberrations (CA) and micronuclei (MN) was investigated in the peripheral lymphocytes of workers occupationally exposed to low or very low concentrations of benzene. The study included 43 exposed workers (all males), namely 19 fuel-tanker drivers and 24 filling-station attendants, and 31 male subjects with no occupational exposure to the toxicant (controls). Benzene exposure was verified by means of environmental monitoring with passive personal samplers (Radiello(®)), and through biological monitoring, i.e. by measurement of urinary trans,trans-muconic acid, S-phenylmercapturic acid and benzene. The frequency of CA and MN in peripheral lymphocytes was determined according to standard procedures. Exposure to benzene was found to be significantly higher for fuel-tanker drivers (median 246.6 μg/m(3)) than for filling-station attendants (median 19.9 μg/m(3)). Both groups had significantly higher exposure than controls (median 4.3 μg/m(3)). No increased frequency of CA and MN was observed in either fuel-tanker drivers or filling-station attendants compared with controls. In all subjects examined as a single group, the frequency of MN was significantly dependent on age. Only in the fuel-tanker drivers was the frequency of MN found to depend not only on age, but also on exposure to benzene. In conclusion, the frequency of MN, but not of CA, could be influenced by exposure to benzene concentrations of up to one order of magnitude lower than the threshold limit value (time-weighted average).
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Authors | Piero Lovreglio, Francesca Maffei, Mariella Carrieri, Maria N D'Errico, Ignazio Drago, Patrizia Hrelia, Giovanni B Bartolucci, Leonardo Soleo |
Journal | Mutation research. Genetic toxicology and environmental mutagenesis
(Mutat Res Genet Toxicol Environ Mutagen)
Vol. 770
Pg. 55-60
(Aug 2014)
ISSN: 1879-3592 [Electronic] Netherlands |
PMID | 25344164
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- muconic acid
- S-phenyl-N-acetylcysteine
- Benzene
- Acetylcysteine
- Sorbic Acid
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Topics |
- Acetylcysteine
(analogs & derivatives, urine)
- Adult
- Benzene
(toxicity)
- Biomarkers
(urine)
- Body Mass Index
- Chromosome Aberrations
(chemically induced)
- Environmental Monitoring
- Humans
- Lymphocytes
(drug effects, metabolism)
- Male
- Micronucleus Tests
- Middle Aged
- Occupational Exposure
(adverse effects)
- Sorbic Acid
(analogs & derivatives, metabolism)
- Young Adult
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