Intravenous iloprost for treatment of critical limb ischemia in patients unsuitable for revascularization.

Abstract

INTRODUCTION:

Whether medical therapy alone may reduce the amputation rates in patients with chronic limb ischemia and who are unsuitable for revascularization is a controversial topic. In this study, we aimed to investigate the effects of 1 week infusion of iloprost in the treatment of patients with chronic limb ischemia.

MATERIALS AND METHODS:

Twenty-seven consecutive patients were included in the study. There were 23 men (85.2%) and 4 women (14.8%) with a mean age of 68.93 ± 14.84 years. Patients were considered eligible if they were unsuitable for surgical and endovascular revascularization. Follow-up was made on 10th day and 6th month and included ankle brachial index and clinical assessment.

RESULTS:

Minor side effects occurred in four patients (16.0%), but the treatment was continued. In-hospital mortality occurred in one patient (4.0%). Another two patients died and four patients received amputation until follow-up (overall mortality 11.1%). There was significant increase in mean ankle-brachial index values between 1st day and 10th day (p < 0.001), between 1st day and 6th month (p < 0.001), and between 10th day and 6th month (p < 0.001).

CONCLUSION:

One-week treatment with iloprost may provide both long lasting symptomatic benefit and may improve hemodynamic parameters, which were shown to predict future amputation.

• Authors: Deniz Çevirme, Eray Aksoy, Yaşar Gökhan Gül, Hasan Erdem, Taylan Adademir, Cengiz Köksal, Kürşat Bozkurt
• Journal: Vascular (Vascular) Vol. 23 Issue 5 Pg. 483-9 (Oct 2015) ISSN: 1708-539X [Electronic] England
• PMID: 25315792 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2014.

Chemical References

• Vasodilator Agents
• Iloprost

Topics

• Adult
• Aged
• Aged, 80 and over
• Amputation, Surgical
• Ankle Brachial Index
• Chronic Disease
• Critical Illness
• Drug Administration Schedule
• Endovascular Procedures (adverse effects)
• Female
• Hospital Mortality
• Humans
• Iloprost (administration & dosage)
• Infusions, Intravenous
• Ischemia (diagnosis, drug therapy, mortality, physiopathology)
• Lower Extremity (blood supply)
• Male
• Middle Aged
• Prospective Studies
• Risk Factors
• Time Factors
• Treatment Outcome
• Vascular Surgical Procedures (adverse effects)
• Vasodilator Agents (administration & dosage)